Demethyleneberberine 25459-91-0 C19H18NO4 98%min Yellow crystal,98%min

Appearance Light yellow crystalline powder Assay(HPLC) 98%min Loss on drying 2.0% max

White crystalline or crystalline powder,no smell,taste bitter, Assay 98.0%-102.0%

Appearance White or almost white crystalline powder Assay(by Potentiometry) 98.0%-101.0%(dried substance) Solubiliy Practically insoluble in water、soluble in ethanol、sparingly soluble in methylene chloride.It shows polymorphism Identification IR or TLC and Coloured reaction Positive Appearance of Solution The solution is clear and not more intensely coloured than reference solution Y6 Tests Specific optical rotation +145°~+154°

White crystalline powder,80% 90% 98% 99%

Light yellow transparent liquid,98%min

White hygroscopic crystalline powder, sour, odorless,99.7%

Appearance White Powder Identity TLC HPLC Assay NLT 98.00% Melting point 238-242 ℃ Loss on drying NMT 1.00% Ash NMT 1.00% Arsenic(MDL0.05) NMT 2ppm Lead(MDL0.02) NMT 2ppm Cadmium(MDL0.02) NMT 1ppm Mercury(MDL0.005) NMT 0.1ppm Total plate count NMT 1000cfu/g Mould&Yeast NMT 100cfu/g E.Coli Negative Salmonella Negative

Appearance Clear, colorless, syrupy liquid with sweet taste Solid Content(%) 69-71 Water(%) 29-31 Sorbitol Assay(%) ≥71.4 Ph 5.0-7.5 Conductivity(µs/cm) ≤10 Relative density(d2020) 1.285-1.315 Reducing sugar(%) ≤0.21 Total sugar(%) ≤8.0 Residue on ignition(%) ≤0.10 Hevy metal(%) ≤0.0005 Lead(pb)(%) ≤0.0001 Arsenic(%) ≤0.0002 Chloride(%) ≤0.001 Sulphate(%) ≤0.005 Nickel(%) ≤0.0002 Total plate count(cfu/g) ≤100

Appearance Yellow powder Assay 98%min Moisture 5% max Sulphated Ash 1% max Odor Characteristic Particle size 100% pass 80 mesh Microbiological Total of bacteria: 1000/g max Fungi: 100/g max Salmonella: Negative Coli: Negative Pesticides Negative Heay metal 10ppm max

Appearance White crystal or powder Assay,HPLC 99%min Loss on drying 3.0% max Heay metals 20ppm max Solubility Insoluble in hotAlcohol Microbiology Total Plate Count: 1000cfu/g max Yeast & Mold: 100cfu/g max E.Coli: N.D S. Aureus:N.D Salmonella:N.D

Appearance Light Yellow Powder Odor Characteristic Assay(Diosmetin) 90%min Moisture 6% max Sulphated Ash 0.2% max Hevy metal 20 ppm max Pesticides Negative Total of bacteria 1000/g max Fungi 100/g max Salmonellz Negative Coli Negative Particle size 100% pass 80 mesh